Calexico is a city in southern Imperial County, California, United States. As of the 2020 census, Calexico had a population of 38,633. Situated on the Mexican border, it is linked economically with the much larger city of Mexicali, the capital of the Mexican state of Baja California. It is about 122 miles (196 km) east of San Diego and 62 miles (100 km) west of Yuma, Arizona. Calexico, along with …